FORMULATION AND IN VITRO EVALUATION OF DIVALPROEX SODIUM BI-LAYERED TABLET
نویسندگان
چکیده
Divalproex sodium is the anticonvulsant agents that used in treatment certain types of seizures. The aim present study to formulate and evaluate divalproex bilayer tablet. Sodium Bi-layer tablets (BLT) were prepared by simple blending punching with HPMC, Xanthan Gum, starch glycolate, MCC, PVP, Magnesium stearate. Optimized formulation was designed on basis best immediate release layer sustained layer. pre post compression parameters evaluated stability studies optimized also performed. FTIR checked no interaction found between drug polymers. tablet batch had shown excellent range weight variation (553.2±1.42) mg, thickness (4.9±0.52) mm, Diameter (1.4±0.13) cm, hardness (5.2±0.31) Kg/cm2, friability (0.35±0.10) % content (99.34±1.6) %. IRL-5 SRL-3 showed 98.13 95.74% from all formulation’s layers. formulated combining both layers IRL- 5 SRL-3. stable at 45 ±2 0C for days. So that, might be suitable KEYWORDS: Divalprox Sodium, Bi-layered Tablet, Formulation, Anticonvulsant
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ژورنال
عنوان ژورنال: Current research in pharmaceutical sciences
سال: 2022
ISSN: ['2250-2688']
DOI: https://doi.org/10.24092/crps.2022.120303